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Nephrotoxic injury is most commonly caused by drugs, primarily antibiotics, analgesics, and contrast agents. In some cases, such as with aminoglycosides and amphotericin B, the drug itself will damage the kidneys. In others, such as with methicillin, sulphonamides, and some contrast agents, the drug provokes an allergic reaction that destroys the kidneys. Some chemicals found in certain drugs and industrial agents damage the kidneys by converting the hemoglobin of red blood cells into methemoglobin, thereby interfering with the blood s transport of oxygen. In hospitals, the most common form of nephrotoxic injury is antibiotic nephropathy, which usually occurs when antibiotics are given to patients with already weakened kidneys. Analgesic nephropathy is another common form of nephrotoxic injury and occurs as a result of long-term abuse of analgesics, usually NSAIDs e.g., ibuprofen. Analgesic nephropathy is most prevalent in women over 30. Lead nephropathy, arising from lead poisoning, and nephropathy, from ingestion of the solvent carbon tetrachloride, are also more common forms of nephrotoxic injury. Uric acid nephropathy is one form of nephropathy that is not caused by exposure to an external toxin; instead, it arises from the body s overproduction of uric acid, usually in persons with diseases of the lymph nodes or bone marrow. that is brilliant.? In the end sustainability and environmental friendliness of the clothing industry depends on the entire life cycle of the garment.
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Posted by at June 26, 2015
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