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The recognition that asthma is a highly heterogeneous disorder in terms of associated environmental factors, clinical expression, response to different therapies, and natural history has opened up the disease beyond allergic sensitization. This has important implications, moving us back to considering asthma as a disease whose origins lie in the airways. Human genetics linked to environmental epidemiology through epigenetics is revealing entirely novel mechanisms and approaches to treatment. The application of cell and molecular biology to different phenotypes of asthma at different points in their natural history will eventually reveal why atopy in some individuals evolves into asthma while in others it does not. An important aspect of this relates to factors that downregulate immune and inflammatory reactions such as regulatory T cells. These are considered in detail in Chapter 4. Bristol-Myers Squibb and AstraZeneca have launched FORXIGATM dapagliflozin, a drug which acts independently of insulin to improve blood sugar levels and lower body weight.

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Posted by at June 23, 2015
Filed in category: Medical news,

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